Among these, the most prevalent genes were: NTRK1, MYCN, secretogranin II (SCG2), pleiotrophin (PTN), neuronal cell adhesion molecule (NRCAM) and ODC1. The IPA of significant gene expression changes, cooperative game theory analysis, chromosomal changes and microRNA affected genes revealed the axonal guidance as the most significant pathway in the pathogenesis of unfavorable NB. This evidence concerns the gene NTRK1 and neuroblastoma.