The underexpression of PIK3R1 was correlated with the overexpression of microRNAs hsa-miR-105, hsa-miR-181a, hsa-miR-181d and hsa-miR-383 in these cases and it was a very frequent expression change in our in silico analysis, however, its significance in NB pathogenesis has not been described yet. The gene discussed is PIK3R1; the disease is neuroblastoma.