The overexpression of HIF1-α target genes was also observed in VHL PCC as matrix metalloproteinase 2 (MMP2) and glucose transporter GLUT1. GLUT1 overexpression in VHL could be correlated with the frequent loss of chromosome 1p34 often observed in MEN2A PCC [74]. This evidence concerns the gene HIF1A and multiple endocrine neoplasia type 2A.