PDX1 and neoplasm: Similarly, IPMNs like lesions from KrasG12D;TGFÎ±;Pdx-1-Cre transgenic mice showed elevated Muc1 and Muc5AC expression at 3 months of age [42] and recent reports also revealed that KrasG12D;P48-Cre; Muc1KO mice had slower tumor progression and metastasis compared to both KrasG12D;P48-Cre and KrasG12D;P48-Cre; MUC1 transgenic animals [43].