The mean COPD exacerbation rate was 2.4 in MetS group compared to 0.68 in the control group. Mean length of each exacerbation was 7.5 days in patients with MetS compared to 5 days in patients without MetS. Serum C-reactive protein, fasting blood glucose, and triglycerides were positively correlated with COPD exacerbation rate. The gene discussed is CRP; the disease is metabolic syndrome.