These studies were undertaken to determine whether increased NGAL expression altered the sensitivity to the chemotherapeutic drug doxorubicin in cancer cell types which are normally sensitive to doxorubicin (breast) and cancer cell types which are normally resistant to doxorubicin (CRC) as well as immortalized breast epithelial cells (MCF-10A) which are not malignant. The gene discussed is LCN2; the disease is colorectal carcinoma.