DNMT3A and Miyoshi myopathy: To determine whether thebone marrow microenvironment (BMM), which triggers the proliferation and supports the survival of MMcells, could affect de novo DNMTs expression, KMS12 and NCI-H929 MM cell lines werecultured for 12 or 24 hours adherent to bone marrow stromal cells (BMSCs) and DNMT3A and DNMT3Blevels were then analyzed by q-RT-PCR (Fig. 1C).