In our experimental model, in vitro transfection of synthetic miR-29bmimics in MM cells promoted apoptosis and cell cycle perturbations, and similar effects wereobserved when DNMT3A and DNMT3B were silenced by shRNAs, just confirming the thought that theseenzymes are valuable targets for anti-tumor treatment. Here, DNMT3B is linked to Miyoshi myopathy.