We first evaluated the expression of DNMT3A, DNMT3B and DNMT1 mRNAs on a dataset of high-densitycDNA-microarrays of primary CD138+ cells from intramedullary MM (n=55) or PCL (n=5)patients and from normal healthy donors (PCs, n=4). This evidence concerns the gene DNMT3A and Miyoshi myopathy.