We observed significant tumor growth inhibition (p<0.05)in mice treated with miR-29b mimics, together with 2-fold increase of miR-29b levels (Fig. 5D) and down-regulation of both DNMT3A and DNMT3B mRNA levels (Fig.5E) as assessed by qRT-PCR analysis of the excised tumors.Notably, miRNAs administration did not produce any significant behavioral changes or weight loss intreated animals. Here, DNMT3B is linked to neoplasm.