TCN2 and primary central nervous system lymphoma: This may explain why the mutant G-allele of Tc2 c.776C>G is associated with progressive demyelination in patients with X-chromosomal adrenoleukodystrophy and the occurrence of white matter T2 hyperintensities on brain MRI in PCNSL patients treated with the MTX-based Bonn protocol (Linnebank et al, 2005, 2009; Semmler et al, 2009).