This common transformation path of thyroid cells in papillary thyroid cancer and Hashimoto thyroiditis has been also attempted to be explained by similarities in activation of the metabolic cycle of tyrosine kinases (PI3k/Akt pathway) and overexpression of p63 protein that leads to apoptosis inhibition [26, 27]. This evidence concerns the gene AKT1 and thyroid gland papillary carcinoma.