ICAM1 and colorectal carcinoma: SDF-1-induced adhesion of DLD-1 and SW48 cells to HUVECs was significantly inhibited by cells incubated with ICAM-1 neutralizing antibody, or transfected with ICAM-1 siRNA, suggesting a direct involvement of ICAM-1 in the adhesive interaction between CRC cells and HUVECs (Figure 2A).