A preferential loss of myosin and myosin-associated proteins has been repeatedlydocumented in patients with CIM using electron microscopy, electrophoreticseparation of myofibrillar proteins, enzyme-cytochemistry andimmuno-cytochemistry [6,30-32].Widespread myosin loss is therefore considered to be essentially pathognomonicof CIM although myosin loss has been reported in other disorders, such asdermatomyositis [33] and cancer cachexia[34]. This evidence concerns the gene MYH14 and cancer.