The role of MyBP-H in theorganization of myosin in the thick filament during myofibrillogenesis[43] and for substituting mutantMyBP-C in cardiomyopathy [44] suggestthat the upregulation of MyBP-H may represent a compensatory mechanism aiming atmaintaining thick filament integrity. Here, MYH14 is linked to cardiomyopathy.