On the sixth postoperative day, following 4 days of leeching, the vascular status of the flap improved, but the patient showed a clinical presentation of septicemia associated with 39.2°C hyperthermia, a white blood cell count of 27,44 109/L and a C-reactive protein (CRP) level increased by 153mg/L. The gene discussed is CRP; the disease is Sepsis.