PICALM and Alzheimer disease: Large genome-wide studies have identified associations between late-onset AD and polymorphisms in the genes clusterin, CR1 (complement receptor 1), SORCS1 (sortilin-related VPS10 domain containing receptor 1) and PICALM (phosphatidylinositol binding clathrin assembly protein) [30-32], observations that were subsequently confirmed by other groups in diverse ethnic cohorts [33-40].