While VEGF-A (also known as VEGF or vascular permeability factor (VPF)) has been identified as the dominant angiogenic factor in many human and experimental murine cancers, acting via VEGFR-1 and VEGFR-2 expressed on endothelial cells lining blood vessels[41-43], the key VEGF family members driving lymphangiogenesis are VEGF-C and VEGF-D (although VEGF-A can also induce lymphangiogenesis) [44-47]. This evidence concerns the gene VEGFA and cancer.