VEGFA and hantavirus infectious disease: Endothelial cell monolayers are not permeabilized by Hantavirus infection alone, and pathogenic Hantaviruses direct endothelium hyperpermeability by sensitizing endothelial cells hyperresponsive to VEGF, or indirectly through the induction of nitric oxide and prostacyclin, and this alters the fluid barrier function of endothelial cell adherence junctions, resulting in enhanced paracellular permeability [39–43].