TP53 and neoplasm: This, in turn, results in hypomethylation within the promoter of tumor suppressor genes as well as a highly immunogenic CTAs [56, 62–64], thereby rendering tumor cells susceptible to CTA-reactive immune responses and suppression of proliferation via expression of p53, as well as rendering these tumor cells more susceptible to Fas L-induced apoptosis by CTA-reactive T cells.