CYP11B1 and adrenal cortex carcinoma: The N-type Ca2+ channel may be involved in aldosterone production, because ω-conotoxin GIVA, a specific N-type Ca2+ channel blocker, significantly suppressed aldosterone and cortisol secretions in NCI-H295R human adrenocortical carcinoma cells without significantly influencing CYP11B2 or CYP11B1 mRNA expression [23].