Among these is GPR83 (also known as GIR, GPR72, or JP05), originally identified as a stress–response element from a murine thymoma cDNA library treated with glucocorticoids and forskolin (Harrigan et al., 1989, 1991; Baughman et al., 1991), and subsequently shown to be highly expressed in several brain regions including the hypothalamus, the cortex, the thalamus, the hippocampus, and the amygdala (Pesini et al., 1998; Brezillon et al., 2001; Wang et al., 2001; Adams et al., 2003; Sah et al., 2005). Here, GPR83 is linked to thymoma.