Several receptors, such as annexin A2 (Romay-Penabad et al., 2009), toll-like receptor 2 and 4 (TLR2, TLR4; Pierangeli et al., 2007), apolipoprotein E receptor 2 (Romay-Penabad et al., 2011), and different signaling pathways, such as molecular nuclear-factor-kB (NFkB; Montiel-Manzano et al., 2007) and p38 mitogen-activated protein kinase (MAPK; Vega-Ostertag et al., 2005), have been reported in APS pathology. The gene discussed is TLR2; the disease is autoimmune polyendocrinopathy.