Since a number of bacterial toxins, such as that of pseudomonas aeruginosa, have the ability to improve MHC class I presentation of an exogenous antigen by facilitating the translocation from endosomal/lysosomal compartments to the cytoplasm, the preferential generation of tumor-reactive CD8+ T cells can be achieved by linking the translocation domain of pseudomonas aeruginosa exotoxin A (ETA(dII)) to a tumor antigen[27]. Here, CD8A is linked to neoplasm.