Furthermore, Gessi et al. have shown that a high incidence of TP53 mutations and the absence of amplification of the c-myc/N-myc genes in adult sPNET, in comparison to pediatric PNET, suggest that adult sPNET should be an independent subset of tumors among CNS-PNETs [3]. This evidence concerns the gene MYC and primitive neuroectodermal tumor.