An algorithmic approach has been suggested by Kawano et al. [2] in which IgG4 kidney disease is suspected when there is evidence of kidney injury (proteinuria, hematuria, and elevated N-acetyl-β-D-glucosaminidase, β2-microglobulin, and/or α1-microglobulin excretions in urinalysis) with characteristic radiologic findings with with either elevated serum IgG level, hypocomplementemia, or elevated serum IgE level. This evidence concerns the gene HLA-G and kidney disorder.