NOS2 and infection: In summary, we have demonstrated that 1) fewer monocytes are recruited to lesion during infection with L. mexicana as compared to L. major, 2) fewer iNOS producing mo-DCs are present in the lesions of L. mexicana infected mice 3) fewer mo-DCs migrate to the dLN node during L. mexicana infection, 4) blocking IL-10R leads to increased monocyte recruitment and a more robust Th1 response during L. mexicana infection, and 5) injection of DCs into the ear at the time of infection with L. mexicana also leads to increased levels of iNOS and IFN-γ.