Additional innate immunity genes previously described in the brain of NPC mice are Mpeg1, Gpnmb, Ctss, Ctsd, Ctsz, Grn, Clec7a, Itgax, Gp49a, Hexb, Lgls3bp, Tyrobp etc [5], [13], [14]. The gene discussed is CTSZ; the disease is nasopharyngeal carcinoma.