In this JIA study, we have evidence from conditional analysis in sJIA that there are likely to be multiple variants contributing to susceptibility: one in IL-20 and another in MAPKAPK2. For persistent oligoarticular JIA, we observed that nominal evidence for association with rs1878672 (intron 3 of IL-10) is increased when considered in a 3-marker haplotype analysis. Here, IL10 is linked to juvenile idiopathic arthritis.