Interestingly, there is no significant difference in cell cycle phase discerned between RCC cells with forced WNT10A expression and those with WNT10A siRNA knockdown; however, β-catenin siRNA-transfected cells showed more obvious G1 arrest [42] than RCC cells with elevated WNT10A or suppressed WNT10A. The gene discussed is WNT10A; the disease is renal cell carcinoma.