LSI analysis revealed that many proteins were significantly correlated to Huntingtin (arfaptin-2 (Arfip2), sacsin (Sacs), heat shock 70 kD protein 1B (Hspa1b), transglutaminase 2 (Tgm2)), chorea (Arfip2, Sacs, disco-interacting protein 2 homolog B (Dip2b)), diabetes (1-acylglycerol-3-phosphate O-acyltransferase 1 (Agpat), glycogen synthase 1 (Gys1), solute carrier family 2(Slc2a1)), and insulin (pyruvate dehydrogenase kinase isozyme 2 (Pdk2), pyruvate kinase 2 (Pkm2), branched chain aminotransferase 2 (Bcat2), carbonic anhydrase 3 (Car3)). This evidence concerns the gene PKM and diabetes mellitus.