INS and Hyperglycemia: Within subjects with similar mean 3-day glycemia, a greater proinflammatory effect was observed in those with the highest hyperglycemic peaks, indicating that optimal management strategies in these patients must be aimed not only at limiting the overall occurrence of hyperglycemia, but also at preventing its most dangerous characteristics (for example, the same overall amount of postprandial hyperglycemia can be achieved without a very high hyperglycemic peak if insulin administration is timed carefully and carbohydrate ingestion is spaced over a longer time).