GH1 and obesity due to melanocortin 4 receptor deficiency: To determine whether the alterations in the GH response to exercise might become more pronounced in children with a greater severity of obesity, we repeated the same study on a larger subject pool (48 obese, 42 age-matched controls), with the obese subdivided in three subgroups with increasing BMI percentile (95–97th, 97–98.5th, and >98.5th BMI%) [31].