Of interest, RvD1 in human monocytes reduces the nuclear translocation of NF-κB, TNF-α induced phosphorylation of IκB (Recchiuti et al., 2011), counteracts NF-κB activation in ALX/FPR2 and DRV1/GPR32 recombinant cells (Krishnamoorthy et al., 2010), dampens acute inflammation in murine dorsal air pouches evoked by local administration of TNF-α (Serhan et al., 2002), and downregulates IKK levels in murine peritonitis (Recchiuti et al., 2011). Here, TNF is linked to peritonitis.