IRF4 and atrial fibrillation: In contrast, 12 genes were found to significantly correlate (negatively) with JC in AF subgroup (Figure 4B, listed in order of decreasing significance): TRAP1, IL2RG, CD40LG, PARP1, TP53, ATM, NFATC2, GZMA, CASP10, PFKFB3, IRF3 and IRF4.