Indeed, Nutlin-3, a cis-imidazoline small molecule that mimics a p53-binding peptide, interferes with MDM2 binding to p53 and proved to be very effective to reduce growth and eventually promote apoptosis in neuroblastoma cells (Barbieri et al., 2006; Van Maerken et al., 2006). The gene discussed is MDM2; the disease is neuroblastoma.