Indeed, p53 restoration already proved to be effective in promoting tumor regression in animal models and several strategies aimed at restoring p53 function (i.e., p53 gene therapy, wild type p53 restoration via small molecole/MDM2-antagonists and mutant-p53 folding restoration) are being currently tested in clinical trials (Cheok et al., 2011). The gene discussed is TP53; the disease is neoplasm.