In 2009, the International Neuroblastoma Risk Group defined seven parameters (stage, age, histologic category, grade of tumor differentiation, status of MYCN oncogene, chromosome 11q status, and DNA ploidy) required to stratify neuroblastoma patients into tentatively homogeneous risk groups and estimated that the high-risk fraction (5-year event free survival <50%) accounted for about 40% of their 8800 patients (Cohn et al., 2009). Here, MYCN is linked to neuroblastoma.