In malignant tumours, however, there was an aberrant epithelial P-cadherin immunoexpression in 64.1% (n = 25) of cases, with a membranous and/or cytoplasmic pattern of distribution.A statistically significant relationship was seen between epithelial P-cadherin expression and malignant mammary lesions (P = 0.0001). This evidence concerns the gene CDH3 and cancer.