The patient was a 33-year-old Caucasian male with advanced AIDS (CD4+ cell count: 59 cells/mm3, HIV-1 RNA level of 308,000 copies/mL) and an extensive history of opportunistic infections including prior disseminated histoplasmosis, disseminated Mycobacterium avium complex (MAC), Pneumocystis jirovecii (PCP) pneumonia, cutaneous varicella-zoster infection, and cytomegalovirus (CMV) gastric ulcer. The gene discussed is CD4; the disease is AIDS.