We previously described genetic associations between polymorphisms in androgen metabolism genes, and risk of developing prostate cancer in South African men [27] and reported differences in genotype and allele frequencies between Senegalese, African-American, Caucasian-American and Ghanaian men for CYP3A4 and SRD5A2 [28]. Here, CYP3A4 is linked to Familial prostate cancer.