These outcomes from N0147 raise two important hypotheses: (1) the possibility that chemotherapy choice may be an important factor in the further development of anti-EGFR mAbs as adjuvant therapy and (2) KRAS mutational status may be an important factor in personalizing adjuvant treatment for resected stage III and possibly high risk-stage II CRC. This evidence concerns the gene KRAS and colorectal carcinoma.