Thirdly, it is also possible that the OA-mediated decrease in oxidative stress may also limit hyperglycemia-induced inactivation of the sarco/endoplasmic reticulum Ca2+-ATPase [51] and electrophysiological alterations (arrhythmias, QT prolongation) [47], [52], [53]. Here, ATP2A3 is linked to Hyperglycemia.