Together with the knowledge of CAD-associated SNPs adjacent to INK4/ARF locus, we came to the hypothesis that individuals may have an intrinsic propensity to p15INK4b/p16INK4a methylation and risk SNPs located in Chr9p21 may function through the contribution of ANRIL to neighboring INK4/ARF methylation. This evidence concerns the gene CDKN2B-AS1 and coronary artery disorder.