VCO induced deactivation of Akt reduced Ser136 phosphorylation of Bad thus allowing it to interact with pro-apoptotic Bcl2 family member Bax to aggregate on mitochondrial membrane resulting release of cytochrome c to the cytosol, which triggers the pathway for caspase cascade in NSCLC cells. The gene discussed is BCL2; the disease is non-small cell lung carcinoma.