HGF and primary hyperoxaluria type 1: These studies showed that whole liver HIR in combination with a mitotic stimulus, such as partial hepatectomy or HGF expression, results in massive liver repopulation and complete correction of the metabolic defect in Gunn rats [16], as well as in a mouse model of PH1 (hepatic alanine∶glyoxylate aminotransferase deficiency) [17], [20].