Our previous research has found out that there was a significantly higher occurrence of HLA-DRB1*09 and HLA-B*46-DRB1*09 in HFRS patients compared with the control group, indicating that HTNV-induced HFRS is associated with a genetic predisposition in the Chinese Han population [22]. This evidence concerns the gene HLA-DRB1 and hemorrhagic fever with renal syndrome.