Moreover, we showed that the people with the haplotype HLA-B*51-DRB1*09 were also susceptible to HFRS, and the allele HLA-B*46 and haplotypes HLA-B*46-DRB1*09 and HLA-B*51-DRB1*09 in patients could contribute to a more severe degree of HFRS and more serious kidney injury. Here, HLA-B is linked to hemorrhagic fever with renal syndrome.