At the whole animal level, administration of bovine Alpi proved to reduce local/systemic inflammation and improve tissue morphology in the mouse polymicrobial sepsis model induced by cecal ligation and puncture (Van Veen et al., 2005), in the rat liver ischemia–reperfusion model (Van Veen et al., 2006), in the murine chronic colitis model induced by dextran sulfate sodium (DSS; Tuin et al., 2009; Campbell et al., 2010; Ramasamy et al., 2011) or TNBS (Martinez-Moya et al., 2012), and in the neonatal necrotizing enterocolitis rat model (Rentea et al., 2012). Here, ALPI is linked to Sepsis.