Most of these adipokines are inflammatory proteins (such as IL-8, PAI-1, MCP-1, IL-6, IL-1Ra, TNFα, sTNF RII, and IL-18), while a few adipokines such as CRP, haptoglobin, and amyloid A are actually acute phase proteins primarily released by the liver in response to mild inflammatory response associated with human obesity. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.