Most of these adipokines are inflammatory proteins (such as IL-8, PAI-1, MCP-1, IL-6, IL-1Ra, TNFα, sTNF RII, and IL-18), while a few adipokines such as CRP, haptoglobin, and amyloid A are actually acute phase proteins primarily released by the liver in response to mild inflammatory response associated with human obesity. Here, CXCL8 is linked to obesity due to melanocortin 4 receptor deficiency.