Genes within this genome region are RAB4B, EGLN2, MIA and CYP2A6. While RAB4B, EGLN2 and MIA are of potentially interest due to their expression in developing animal and human lung (Groenman et al, 2007; Lin et al, 2008; Otulakowski et al, 2009), CYP2A6 has previously been associated with lung cancer and has been shown to be involved in nicotine metabolism (Hukkanen et al, 2005; London et al, 1999; Nakajima et al, 1996), in particular of the major nicotine metabolite cotinine (Thorgeirsson et al, 2010). This evidence concerns the gene MIA and lung cancer.