While IRF3 signaling is important for mediating the innate immune response, pathologic IRF3 signaling, via abnormal TLR signaling in non-immune cells for example, can lead to the development of autoimmune and inflammatory diseases such as diabetes (Types 1 and 2), atherosclerosis, autoimmune thyroid disease, inflammatory bowel disease, sepsis, and even cancer [30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45]. Here, IRF3 is linked to Sepsis.