Transductional targeting was performed using antibodies that recognize the PSCA (Prostate stem cell antigen), the MUC4 and the Claudin 18 variant 2 antigens (CLDN18), all chosen according to published data showing specific expression or overexpression of these proteins in pancreatic adenocarcinomas (see Background section, Figure 1). This evidence concerns the gene CLDN18 and pancreatic adenocarcinoma.