While among the ligands analyzed the BMP2, BMP4, BMP6, BMP7, TGFB1 and TGFB2 genes did not show significant differences between chondrosarcomas of different histological grades, TGFB3 was significantly higher expressed in grade III compared to grade I chondrosarcoma (2-fold, p=0.006). This evidence concerns the gene BMP4 and chondrosarcoma.