Moreover, a whole-genome approach using a human gene promoter tiling microarray platform to identify genome-wide and gene-specific epigenetic signatures of breast cancer metastasis to lymph nodes led to functional associations between the methylation status and expression of genes CDH1, CST6, EGFR, SNAI2 and ZEB2 associated with epithelial-mesenchymal transition [41]. This evidence concerns the gene CST6 and breast carcinoma.