Furthermore, repeated ultraviolet B irradiation on human keratinocytes enhanced FOXM1-associated genomic instability in the form of loss of heterozygosity (LOH) and copy number aberrations (CNA) perturbing genomic loci containing large number of genes, for example, epidermal growth factor receptor (EGFR), insulin-like growth factor 2 receptor (IGF2R), and insulin-like growth factor binding protein 1/3 (IGFBP1/3), which have been previously linked to oncogenesis of human squamous cell carcinoma (Teh et al., 2010). The gene discussed is IGF2R; the disease is squamous cell carcinoma.