CD40 and neoplasm: By linking anti-neu mAb directed against a tumor antigen and anti-CD40 mAb on NP’s surface, they generated an anti-tumor response resulting in tumor rejection with high production of Th1-proinflammatory cytokines, a stark reduction of regulatory T cells within the tumor and activation of specific cytotoxic immune response (Dominguez and Lustgarten, 2010).