HMGB1 and neoplasm: Called “immunogenic cell death” (ICD), this type of tumor cell death is defined by at least three signals: calreticulin (CRT) exposure (Obeid et al., 2007b; Zitvogel et al., 2010), release of high mobility group box-1 (HMGB-1; Apetoh et al., 2007a,2007b), and ATP (Ghiringhelli et al., 2009; Martins et al., 2012).