These cytokines secreted by tumor cells favor an immune deviation, characterized by a shift toward a more Th2-polarized response that suppresses the establishment of an adaptive cellular response involving effector CD8+ T-lymphocytes (Maeda and Shiraishi, 1996; Shurin et al., 1999; Ribas et al., 2000). The gene discussed is CD8A; the disease is neoplasm.