In order to elicit a protective anti-tumor immune response, APC such as dendritic cells and macrophages have to internalize the tumor cells, transport them to the draining lymph nodes, and process the tumor antigens into peptides that are presented by MHC class I and class II molecules for the activation of tumor specific CD8+ and CD4+ T cells, respectively [11,12,13]. Here, HLA-C is linked to neoplasm.