In a univariable logistic regression analysis of factors associated with TD during IFN-αbased therapy; gender, age, HCV genotype, cirrhosis, and regimen of IFN-α-based therapy were analyzed; only gender was significantly associated enough to justify an inclusion in the equation(OR, 3.64; 95%CI, 1.7–5.8, P = 0.0001). Here, IFNA1 is linked to Cirrhosis.